Scientists identify immunological profiles of people who make powerful HIV antibodies
People living with HIV who naturally produce broadly neutralizing antibodies (BNAbs) that may help suppress the virus have different immunological profiles than people who do not, researchers report. While bNAbs cannot completely clear HIV infections in people who already acquired the virus, scientists believe a successful preventive HIV vaccine must induce bNAbs. Defining how to safely replicate these attributes in HIV-uninfected vaccine recipients may lead to better designed experimental vaccines to protect against HIV. Ref. Source 7z.
New vaccination strategies coach immune system to make HIV-neutralizing antibodies
New approaches that could spur the human body to produce HIV-blocking antibodies have been successful in mice mimicking the human immune system, according to five new studies. Ref. Source 1h.
If they're waiting on the immune system to catch up with HIV then they will have a long wait. There has been some significant breakthroughs but I think a vaccine is one of the best ways to stop the spread.
Potent antibody that neutralizes nearly all HIV strains identified
Scientists have identified an antibody from an HIV-infected person that potently neutralized 98 percent of HIV isolates tested, including 16 of 20 strains resistant to other antibodies of the same class. The remarkable breadth and potency of this antibody, named N6, make it an attractive candidate for further development to potentially treat or prevent HIV infection, say the researchers. Ref. Source 8g.
Protein that activates immune response harms body's ability to fight HIV
Temporarily blocking a type of protein, called type I interferon, can restore immune function and speed up viral suppression during treatment with anti-viral drugs for people with chronic infection of the virus that causes AIDS, findings from a study in animals appear to demonstrate. Ref. Source 8g.
Discovery of an HIV reservoir marker: New avenue toward eliminating the virus
A marker has been identified that makes it possible to differentiate "Dormant" HIV-infected cells from healthy cells. This discovery will make it possible to isolate and analyze reservoir cells which, by silently hosting the virus, are responsible for its persistence even among patients receiving antiviral treatment, whose viral load is undetectable, say scientists. Ref. Source 1b.