Pulmonary fibrosis caused by single transcription factor. To date, the molecular basis of pulmonary fibrosis has been poorly understood. Scientists have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of the disease. In research on mice, the progress of the disease was able to be halted using drugs that boost FoxO3 activity. The researchers are hoping they may have found a possible approach to treatment. Source 1x.
Lung-on-a-chip simulates pulmonary fibrosis. New biotechnology could make testing potential medicine for pulmonary fibrosis, one of the most common and serious forms of lung disease, quicker and less expensive. The innovation, lung-on-a-chip technology, relies on the same technology used to print electronic chips, photolithography. Source 9k.